Resource Type

Journal Article 574

Conference Videos 11

Year

2024 1

2023 49

2022 53

2021 66

2020 31

2019 39

2018 36

2017 34

2016 27

2015 37

2014 32

2013 23

2012 14

2011 9

2010 24

2009 34

2008 16

2007 19

2006 6

2005 5

open ︾

Keywords

China 5

genetic algorithm 5

artificial neural network 4

influence factor 4

influencing factor 4

risk factor 4

vector control 4

Artificial intelligence 3

COVID-19 3

FEM 3

human immunodeficiency virus (HIV) 3

simulation 3

β 2

-catenin 2

Artificial intelligence 2.0 2

B p65 (NF-κ 2

B p65) 2

Bioaccessibility 2

Deep learning 2

open ︾

Search scope:

排序： Display mode:

Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composedof the human heavy chain and the rat light chain

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 584-595 doi: 10.1007/s11684-021-0844-7

Abstract: In this study, a recombinant FVIII cDNA encoding a human/rat hybrid FVIII with an enhanced procoagulantPlasmids containing human FVIII heavy chain (hHC), human light chain (hLC), and rat light chain (rLC)In conclusion, the application of the hybrid FVIII (hHC+ rLC) via an AAV-delivered gene therapy substantially

Keywords： hemophilia A     adeno-associated virus (AAV)     human/rat hybrid factor VIII     gene therapy     dual chain strategy    

HTML PDF Collect

Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic factorand tropomyosin-related kinase B in rat hippocampus

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 411-415 doi: 10.1007/s11684-012-0226-2

Abstract: Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood disorders and tropomyosin-relatedketamine-elicited antidepressant effects, which is associated with the increased levels of BDNF and TrkB in rat

Keywords： tramadol     ketamine     antidepressant     brain-derived neurotrophic factor     tropomyosin-related kinase B    

HTML PDF Collect

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: protein kinases (ERKs) pathway of HBx on glomerular mesangial cell (GMC) proliferation and tumor necrosis factor

Keywords： virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor necrosis factor    

HTML PDF Collect

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract: Recent clinical trials involving the use of a self-complementary adeno-associated virus serotype 8-humancodon-optimized factor IX (AAV8-hFIXco) vector demonstrated encouraging efficacy with hFIX expressionto obtain a higher expression level of hFIX that potentiates the coagulant capacity of recipients, human

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

HTML PDF Collect

662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 283-285 doi: 10.1007/s11684-008-0053-7

Abstract: The aim of this paper is to report a new coding variance of the gene, a candidate for autoimmune diseases. We found the variation in two families with type 2 diabetes mellitus by D-HPLC mutation screening method and confirmed our results by direct sequencing and PCR-RFLP. Although without changing the amino acid coding, the variance may have an effect on codon usage and play a role in disease development, such as type 2 diabetes mellitus. However, we cannot define the role of this variance because the frequency of the minor allele is low in the Chinese population and no homozygote of the variance was found. More research in multiple populations will be necessary to define the role of this variance.

Keywords： D-HPLC mutation     development     autoimmune     PCR-RFLP     candidate    

HTML PDF Collect

Introduction to the special issue on the VIII Latin-American Congress on Mechanical Engineering

Marco CECCARELLI,René-Vinicio SÁNCHEZ

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 3,   Pages 219-220 doi: 10.1007/s11465-015-0356-8

HTML PDF Collect

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

HTML PDF Collect

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 303-308 doi: 10.1007/s11684-009-0060-3

Abstract: on the invasion and the related protein expression of Hela cells and the role of hypoxia inducible factorIt was concluded that the effects of hypoxia on the invasion of human cervical cancer Hela cells and

Keywords： hypoxia     actin     β     -catenin     E-cadherin     invasion    

HTML PDF Collect

c-Fos expression in rat brainstem following intake of sucrose or saccharin

Ke Chen, Jianqun Yan, Jinrong Li, Bo Lv, Xiaolin Zhao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 294-301 doi: 10.1007/s11684-011-0144-8

Abstract: To examine whether the activation of brainstem neurons during intake of a sweet tastant is due to orosensory signals or post-ingestive factors, we compared the distribution of c-Fos-like immunoreactivity (c-FLI) in the nucleus of the solitary tract (NST) and parabrachial nucleus (PBN) of brainstem following ingestion of 0.25 M sucrose or 0.005 M saccharin solutions. Immunopositive neurons were localized mainly in the middle zone of the PBN and four rostral-caudal subregions of the NST. Intake of sucrose increased the number of FLI neurons in almost every subnucleus of the PBN (F = 7.610, = 0.023), in addition to the caudal NST at the level of the area postrema (F = 10.777, = 0.003) and the NST intermediate zone (F = 7.193, = 0.014). No significant increase in the number of c-Fos positive neurons was detected in response to saccharin ingestion, although there was a trend towards a modest increase in a few select NST and PBN nuclei. These results suggest that the PBN and NST may be involved in sweet taste perception and modulation of sweet tastant intake, but the significantly enhanced intensity of Fos expression induced by sucrose indicates that PBN/NST neuronal activity is driven by the integrated effects of sweet taste sensation and post-ingestive signals.

Keywords： c-Fos     parabrachial     the nucleus of the solitary tract     sweet tastant     rat    

HTML PDF Collect

Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 362-372 doi: 10.15302/J-FASE-2018206

Abstract:

This study compared proteome profiles and morphological changes of rat jejunum in response to different

Keywords： Hippo signaling pathway     meat protein     PEPT1     proteome analysis     rat jejunum    

HTML PDF Collect

A modified chronic ocular hypertension rat model for retinal ganglion cell neuroprotection

Lichun Zhong

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 367-377 doi: 10.1007/s11684-013-0266-2

Abstract:

This study aimed to modify a chronic ocular hypertension (OHT) rat model to screen for potential compoundsThe OHT rat model was created via the injection of a hypertonic saline solution into the episcleral veins

Keywords： chronic ocular hypertension     intraocular pressure     retinal ganglion cells     neuroprotection     glaucoma    

HTML PDF Collect

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: studied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell lines (humanhepatoma cell line HepG2, human colon cancer cell line LoVo, and human gastric cancer cell line AGS)and nontumor cell lines (human embryonic liver cell line L02 (L02 cells) and human embryonic kidney

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

HTML PDF Collect

Spontaneous firing properties of rat medial vestibular nucleus neurons in brain slices by infrared visual

XIA Jiao, KONG Weijia, ZHU Yun, ZHOU Yan, ZHANG Yu, GUO Changkai

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 264-268 doi: 10.1007/s11684-008-0050-x

Abstract: paper describes the preparation procedure of brainstem slices and the spontaneous firing properties of ratBy infrared differential interference contrast technique, neurons of rat MVN were visualized directly

Keywords： resistance     infrared     infrared videomicroscopy     depressive     after-hyperpolarization potential    

HTML PDF Collect

Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 57-60 doi: 10.1007/s11684-009-0003-z

Abstract: The aim of the present study was to construct the lentiviral RNA interference (RNAi) vector of rat OBRbreducing gene expression were further confirmed by real-time polymerase chain reaction in transfected ratspecifically reduced the expression of OBRb mRNA by approximately 80% compared with controls in transfected ratThe successful construction of rat lentivirus vectors expressing OBRb-specific shRNA may be useful for

Keywords： receptors     leptin     RNA interference     lentivirus vector    

HTML PDF Collect

System dynamics analytical modeling approach for construction project management research: A critical review and future directions

Xiaoxiao XU, Patrick X. W. ZOU

Frontiers of Engineering Management 2021, Volume 8, Issue 1,   Pages 17-31 doi: 10.1007/s42524-019-0091-7

Abstract: rework, and change management; (3) risk management; (4) resource management; (5) decision making; (6) hybridfuture research directions, namely, integration of SD with other methods, uncertainty analysis, and humanfactor analysis.

Keywords： system dynamics     construction management     problem and recommendation     research directions     literature review     humanfactor    

HTML PDF Collect

Title Author Date Type Operation

Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composedof the human heavy chain and the rat light chain

Journal Article

Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic factorand tropomyosin-related kinase B in rat hippocampus

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Journal Article

Introduction to the special issue on the VIII Latin-American Congress on Mechanical Engineering

Marco CECCARELLI,René-Vinicio SÁNCHEZ

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Journal Article

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Journal Article

c-Fos expression in rat brainstem following intake of sucrose or saccharin

Ke Chen, Jianqun Yan, Jinrong Li, Bo Lv, Xiaolin Zhao

Journal Article

Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Journal Article

A modified chronic ocular hypertension rat model for retinal ganglion cell neuroprotection

Lichun Zhong

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

Spontaneous firing properties of rat medial vestibular nucleus neurons in brain slices by infrared visual

XIA Jiao, KONG Weijia, ZHU Yun, ZHOU Yan, ZHANG Yu, GUO Changkai

Journal Article

Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Journal Article

System dynamics analytical modeling approach for construction project management research: A critical review and future directions

Xiaoxiao XU, Patrick X. W. ZOU

Journal Article